Multidrug transporter MRP4/ABCC4 as a key determinant of pancreatic cancer aggressiveness.
Sahores A, Carozzo A, May M, Gómez N, Di Siervi N, De Sousa Serro M, Yaneff A, Rodríguez-González A, Abba M, Shayo C, Davio C.
Sahores A, et al.
Sci Rep. 2020 Aug 26;10(1):14217. doi: 10.1038/s41598-020-71181-w.
Sci Rep. 2020.
PMID: 32848164
Free PMC article.
Contrarily, MRP4 overexpression significantly increased BxPC-3 growth rate, produced a switch in the expression of EMT markers, and enhanced experimental metastatic incidence. Altogether, our results indicate that MRP4 is associated with a more aggressive phenotype in PDAC …
Contrarily, MRP4 overexpression significantly increased BxPC-3 growth rate, produced a switch in the expression of EMT markers, and enhanced …